As a woman who has lost both her mother and grandmother to cancer that was diagnosed in their 40s, Angelina Jolie understandably views her 50th birthday as a goal.
The actress had a double mastectomy and removed her ovaries and fallopian tubes before she turned 40 in a bid to avoid the disease and now admits in a candid interview that she will only feel like she has "made it" when she reaches the milestone birthday.
"Both of the women in my family, my mother and my grandmother started dying in their 40s," she told told US Vogue. "I’m 40. I can’t wait to hit 50 and know I made it."
In 2013 the Maleficent star went public about preventative surgery to reduce her 87% risk of contracting breast cancer, then in March she revealed she'd had her ovaries and fallopian tubes removed after finding she had a 50% chance of developing ovarian cancer.
She confides in the interview that going through the menopause early has made her feel "grounded as a woman" but wryly describes the changes to her hormones as "interesting."
Angelina, who was photographed for the magazine by Annie Leibovitz, is promoting her new film By The Sea, which she wrote, directed and stars in alongside her husband Brad Pitt - the couple's first onscreen outing together since they met on the set of 2005 romcom Mr & Mrs Smith.
In the 1970s-set drama, which Angelina wrote in the wake of her mother's death eight years ago, the pair play a couple struggling to save their marriage - but the actress insists the work is not autobiographical.
"Brad and I have our issues," she concedes, "but if the characters’ were even remotely close to our problems we couldn’t have made the film."
By The Sea is out next month in the US and is due to hit UK cinemas on 11 December.
Images: Rex Features