UPDATE: Jamie did it in a knock-out black pleated shirt dress with slick up do and statement red lips.

A US actress is set to become the first woman with Down's Syndrome to model at New York Fashion Week.

Jamie Brewer, who stars in American Horror Story, will turn model for designer Carrie Hammer's show this afternoon - on the first day of NYFW.

Brewer, who will walk in an original design by Hammer, told Today: "Young girls and even young women … [see me] and say ‘hey, if she can do it so can I.'"

"It’s a true inspiration being a role model for any young women to [encourage them] in being who they are and showing who they are."

The 30-year-old is a longtime advocate for people with intellectual disabilities and successfully lobbied the Texas government to pass a law to abolish using the word "retarded" in state legislation, as well as to improve recognition of the needs of Texans with disabilities.

And Hammer is no stranger to creating pioneering runway moments. She debuted at New York Fashion Week last February using a model in a wheelchair - another first for NYFW - in her Role Models Not Runway Models show.

Meet the first woman with Down's Syndrome to model at New York Fashion Week