Angelina Jolie has confirmed that she will play Cleopatra in an upcoming re-make of the 1963 epic and also hinted that she will retire from cinema after making the epic.
Speaking to BBC Radio 5 Live to promote her new movie Maleficent, the 38-year-old actress revealed that she was in talks for a film revival of the legendary Egyptian queen.
"We've been working on it," Jolie said. "There's been lots of different ideas of directors and lots of different discussions. The script has been written by Eric Roth, who is a dear friend and a brilliant writer."
Suggesting that this role may be her last, she added:
"She [Cleopatra] is complicated, it's complicated to get this one right. I think we're getting there. It's getting close.
"I imagine the preparation for it is going to be big. It's one of those that you think maybe that's the one you put everything into and that's where you end it, that's where you finish - in a great way. What could you do beyond that one?"
Jolie first indicated she may give up acting at a press conference for Maleficent last month.
The Hollywood star said she wanted to focus on directing and her humanitarian work as a special envoy for the United Nations High Commissioner for Refugees (UNHCR).
"I've had a wonderful career and I'm very happy to have had all the opportunities to tell stories and work for as long as I have," she said.
"I'm sure there will be more films but I am happy I am able to be selective and have fun with characters like this but I would like to focus on writing and directing and above all I would like to focus more on my work with the UN."
Jolie's second go in the director's seat comes with this year's war biopic Unbroken.
The film chronicles the life of Louis Zamperini, an Olympic runner who was taken prisoner by Japanese forces during World War II, and hits cinemas in December.
The Maleficent star previously directed In the Land of Blood and Honey, a 2011 film set during the Bosnian War.
Rumours of another film version of Cleopatra have been doing the rounds for the past few years. It's thought that the screenplay will be based on Stacy Schiff's 2010 biography Cleopatra: A Life and directors James Cameron, Ang Lee and David Fincher have all been linked to the project at various points.
Elizabeth Taylor and Richard Burton famously met and fell in love on the set of the original Cleopatra in 1963, when they were both married to other people.
Their chemistry was instant - so much so, that the director asked whether he could say cut during their first kiss scene because it went on for so long.
Their affair caused an international sensation, with the Vatican branded their relationship "erotic vagrancy".
"Richard and I had an incredible chemistry together. We couldn't get enough of each other," Taylor later confirmed.
Of course, the affair did no harm at all to the film's success; it was a runaway hit that went down in movie history as a classic of golden age cinema.