Directly addressing Priebus in her Netflix show, Chelsea Does Online, she said: “Who the fuck are you tell someone to smile?”

The 41-year-old continued: “This is just another example of how men feel like they can belittle every woman in the world and order up a smile. It’s not just Hillary; they tell actresses to smile, they tell female athletes to smile… even paintings aren’t safe.”

Referring to the Leonardo Da Vinci’s iconic portrait of the Mona Lisa, and the debate surrounding her “smile”, Handler joked: “Mona’s obviously been on her period for the last 500 years, so leave a bitch alone.”

She went on to add: “It happens to women on the daily commute, it used to happen to me – until men realised I suffer from a condition known as Resting Chelsea Face.

“They say it takes more muscles to frown, and I say, well good, then my face is getting one hell of a work out.”

Chelsea Handler’s powerful message to men who tell women to smile