Oh played Christina Yang, the no-nonsense cardiac surgeon hopeful who became Meredith Grey’s (Ellen Pompeo) “person” on Grey’s Anatomy. The pair’s friendship, at times antagonistic but built on a foundational stone of fierce loyalty and love, is still one of the defining relationships from the series, more memorable to a lot of fans than the disposable love interests wheeled through season after season.

Oh left Grey’s Anatomy at the end of season ten in 2014, a decision that the actress did not take lightly at the time. She has said that she went to therapy to process leaving the show, and that she gave herself two years to work through the emotions of saying goodbye.

“Creatively, I really feel like I gave it my all, and I feel ready to let her go,” Oh told The Hollywood Reporter in 2013. “It’s such an interesting thing to play a character for so long and to actually get the sense that she wants to be let go as well. [Christina] wants to be let go, and I am ready to let her go… I want to cry right now. Grey’s has been the most important role of my life.”

The one question Sandra Oh is always asked in interviews